Enhanced target detection in CCTV network system using colour constancy

The focus of this research is to study how targets can be more faithfully detected in a multi-camera CCTV network system using spectral feature for the detection. The objective of the work is to develop colour constancy (CC) methodology to help maintain the spectral feature of the scene into a constant stable state irrespective of variable illuminations and camera calibration issues. Unlike previous work in the field of target detection, two versions of CC algorithms have been developed during the course of this work which are capable to maintain colour constancy for every image pixel in the scene: 1) a method termed as Enhanced Luminance Reflectance CC (ELRCC) which consists of a pixel-wise sigmoid function for an adaptive dynamic range compression, 2) Enhanced Target Detection and Recognition Colour Constancy (ETDCC) algorithm which employs a bidirectional pixel-wise non-linear transfer PWNLTF function, a centre-surround luminance enhancement and a Grey Edge white balancing routine. The effectiveness of target detections for all developed CC algorithms have been validated using multi-camera ‘Imagery Library for Intelligent Detection Systems’ (iLIDS), ‘Performance Evaluation of Tracking and Surveillance’ (PETS) and ‘Ground Truth Colour Chart’ (GTCC) datasets. It is shown that the developed CC algorithms have enhanced target detection efficiency by over 175% compared with that without CC enhancement. The contribution of this research has been one journal paper published in the Optical Engineering together with 3 conference papers in the subject of research

Comparative noise performance of a coded aperture spectral imager

Novel types of spectral sensors using coded apertures may offer various advantages over conventional designs, especially the possibility of compressive measurements that could exceed the expected spatial, temporal or spectral resolution of the system. However, the nature of the measurement process imposes certain limitations, especially on the noise performance of the sensor. This paper considers a particular type of coded-aperture spectral imager and uses analytical and numerical modelling to compare its expected noise performance with conventional hyperspectral sensors. It is shown that conventional sensors may have an advantage in conditions where signal levels are high, such as bright light or slow scanning, but that coded-aperture sensors may be advantageous in low-signal condition

Interleukin-2/interferon-α2a/13-retinoic acid-based chemoimmunotherapy in advanced renal cell carcinoma: results of a prospectively randomised trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN)

We performed a prospectively randomised clinical trial to compare the efficacy of four subcutaneous interleukin-2-(sc-IL-2) and sc interferon-α2a (sc-IFN-α2a)-based outpatient regimens in 379 patients with progressive metastatic renal cell carcinoma. Patients with lung metastases, an erythrocyte sedimentation rate ⩽70 mm h−1 and neutrophil counts ⩽6000 μl−1 (group I) were randomised to arm A: sc-IL-2, sc-IFN-α2a, peroral 13-cis-retinoic acid (po-13cRA) (n=78), or arm B: arm A plus inhaled-IL-2 (n=65). All others (group II) were randomised to arm C: arm A plus intravenous 5-fluorouracil (iv-5-FU) (n=116), or arm D: arm A plus po-Capecitabine (n=120). Median overall survival (OS) was 22 months (arm A; 3-year OS: 29.7%) and 18 months (arm B; 3-year OS: 29.2%) in group I, and 18 months (arm C; 3-year OS: 25.7%) and 16 months (arm D; 3-year OS: 32.6%) in group II. There were no statistically significant differences in OS, progression-free survival, and objective response between arms A and B, and between arms C and D, respectively. Given the known therapeutic efficacy of sc-IL-2/sc-INF-α2a/po-13cRA-based outpatient chemoimmunotherapies, our results did not establish survival advantages in favour of po-Capecitabine vs iv-5-FU, and in favour of short-term inhaled-IL-2 in patients with advanced renal cell carcinoma receiving systemic cytokines

Phase III trial of postoperative cisplatin, interferon alpha-2b, and 5-FU combined with external radiation treatment versus 5-FU alone for patients with resected pancreatic adenocarcinoma – CapRI: study protocol [ISRCTN62866759]

After surgical intervention with curative intention in specialised centres the five-year survival of patients with carcinoma of the exocrine pancreas is only 15%. The ESPAC-1 trial showed an increased five-year survival of 21% achieved with adjuvant chemotherapy. Investigators from the Virginia Mason Clinic have reported a 5-year survival rate of 55% in a phase II trial evaluating adjuvant chemotherapy, immunotherapy and external-beam radiation. DESIGN: The CapRI study is an open, controlled, prospective, randomised multi-centre phase III trial. Patients in study arm A will be treated as outpatients with 5-Fluorouracil; Cisplatin and 3 million units Interferon alpha-2b for 5 1/2 weeks combined with external beam radiation. After chemo-radiation the patients receive continuous 5-FU infusions for two more cycles. Patients in study arm B will be treated as outpatients with intravenous bolus injections of folinic acid, followed by intravenous bolus injections of 5-FU given on 5 consecutive days every 28 days for 6 cycles. A total of 110 patients with specimen-proven R0 or R1 resected pancreatic adenocarcinoma will be enrolled. An interim analysis for patient safety reasons will be done one year after start of recruitment. Evaluation of the primary endpoint will be performed two years after the last patients' enrolment. DISCUSSION: The aim of this study is to evaluate the overall survival period attained by chemo-radiotherapy including interferon alpha 2b administration with adjuvant chemotherapy. The influence of interferon alpha on the effectiveness of the patients' chemoradiation regimen, the toxicity, the disease-free interval and the quality of life are analysed. Different factors are tested in terms of their potential role as predictive markers

Illumination invariance and shadow compensation via spectro-polarimetry technique

A major problem for obtaining target reflectance via hyperspectral imaging systems is the presence of illumination and shadow effects. These factors are common artefacts, especially when dealing with a hyperspectral imaging system that has sensors in the visible to near infrared region. This region is known to have highly scattered and diffuse radiance which can modify the energy recorded by the imaging system. Shadow effect will lower the target reflectance values due to the small radiant energy impinging on the target surface. Combined with illumination artefacts, such as diffuse scattering from the surrounding targets, background or environment, the shape of the shadowed target reflectance will be altered. In this study we propose a new method to compensate for illumination and shadow effects on hyperspectral imageries by using a polarization technique. This technique, called spectro-polarimetry, estimates the direct and diffuse irradiance based on two images, taken with and without a polarizer. The method is evaluated using a spectral similarity measure, angle and distance metric. The results of indoor and outdoor tests have shown that using the spectro-polarimetry technique can improve the spectral constancy between shadow and full illumination spectra